nTSI LLC,* a Joint Venture, Huntsville, Alabama, is being awarded a competitive, cost-plus-fixed-fee, level-of-effort contract with a total value of $637,123,220. Under this new contract, the contractor will support the layered Missile Defense System (MDS) and help advance concepts for future MDS inclusion. Activities will include supporting the government with: threat systems engineering; advanced technology; directed energy; hypersonic defense engineering; space systems engineering; U.S-Israeli Cooperative Program engineering; cybersecurity systems engineering; test analyses and reporting; lethality, hit assessment/kill assessment, and collateral effects and consequence management; and, concurrent test, training, and operations engineering. The work will be performed at Redstone Arsenal, Alabama; Fort Belvoir, Virginia; Kirtland Air Force Base, New Mexico; Tel Aviv, Israel; and Schriever Space Force Base, Colorado. The performance period is from February 2023 to August 2030. This contract was competitively procured via publication on the SAM.gov website with two proposals received. Fiscal 2023 research, development, test and evaluation funds in the amount of $8,302,098.15 are being obligated at time of award. The Missile Defense Agency, Huntsville, Alabama, is the contracting activity (HQ0858-23-C-0001).